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2 article(s) from Turnbull, W Bruce

Carbohydrate inhibitors of cholera toxin

Vajinder Kumar and
W. Bruce Turnbull

Beilstein J. Org. Chem. 2018, 14, 484–498, doi:10.3762/bjoc.14.34

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Graphical Abstract

Figure 1: a) Ribbon and b) surface depictions of the cholera toxin: A1₁ domain in light blue; A1₂ domain in d...

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Figure 2: a) Structure of the cholera toxin showing the location of its carbohydrate binding sites and the st...

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Figure 3: Bernardi and co-workers’ designed oligosaccharide mimetics of GM₁.

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Figure 4: Structure of monomeric ligands. X = amino acid residues, aminoalkyl, 1,2,3 triazoles; n = 1, 2; R =...

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Figure 5: Bivalent inhibitor designed and synthesised by Pickens et al.

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Figure 6: Bivalent inhibitor designed and synthesized by Arosio et al.

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Figure 7: Bivalent inhibitors designed and synthesised by Leaver and Liu.

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Figure 8: Bivalent and tetravalent inhibitor designed and synthesised by Pieters, and Bernardi et al.

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Figure 9: Cyclic inhibitors synthesised by Kumar et al. for CT.

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Figure 10: The star-shaped inhibitors reported by Fan, Hol and co-workers.

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Figure 11: Differently sized cyclic decavalent peptide core designed by Zhang et al.

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Figure 12: Calix[5]arene core-based pentavalent inhibitor designed by Garcia-Hartjes et al.

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Figure 13: Corannulene core-based pentavalent inhibitor designed by Mattarella et al.

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Figure 14: Pentavalent inhibitor designed by Pieters and co-workers.

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Figure 15: Neoglycoprotein inhibitor based on a non-binding mutant of CTB.

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Figure 16: Octavalent inhibitor designed by Pieters, Bernardi and co-workers.

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Figure 17: Hetero-bifunctional inhibitor designed by Bundle and co-workers.

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Figure 18: Glycopolymers with exchangeable sugar ligands and variable length linkers.

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Album

Review

Published 21 Feb 2018

Full text

Benzyne arylation of oxathiane glycosyl donors

Martin A. Fascione and
W. Bruce Turnbull

Beilstein J. Org. Chem. 2010, 6, No. 19, doi:10.3762/bjoc.6.19

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Graphical Abstract

Scheme 1: a) Boons’ chiral auxiliary-based approach to α-stereoselective glycosylations. b) Modified strategy...

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Scheme 2: Benzyne generation from 1-ABT.

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Scheme 3: Oxathiane donor synthesis.

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Scheme 4: Arylation/acetate glycosylation of oxathiane glycosyl donors.

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Album

Supp Info

Preliminary Communication

Published 22 Feb 2010

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